Thiabendazole: spot the regiochemistry flaw

Single question

One-step condensation between o-phenylenediamine and thiazole-4-carboxylic acid to give thiabendazole. Reactants and reaction class match. Check which benzimidazole carbon the thiazole ends up on.

Benzimidazole formation regiochemistry

o-Phenylenediamine + carboxylic acid closes at C2

C5 vs C2 substitution on benzimidazole

Find the flaw

Click the step that contains the flaw, or pick “No flaw” if you think every step is correct.

Discussion

0 comments

Loading discussion...